CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR. Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov).

Cantargia AB meddelade idag uppdaterade interimsresultat från den pågående kliniska studien med antikroppen CAN04, som blockerar interleukin-1 receptor accessory protein (IL1RAP), i kombination

CAN04 är en Cantargia has provided updated interim data from its Phase IIa CANFOUR trial, reporting new efficacy data from the combination arms of the study investigating CAN04 (anti-IL1RAP) in first-line NSCLC and PDAC. These new Phase IIa data, combined with initial interim data reported in December 2019, continue to support the hypothesis that CAN04 has a synergistic benefit with chemotherapy, in our The CANFOUR trial investigates the antibody CAN04 for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. CAN04 is targeted against interleukin 1 receptor accessory protein (IL1RAP) and is studied both as single agent therapy as well as in combination with standard first line chemotherapy in NSCLC and pancreatic cancer, respectively. CAN04 i test med Keytruda Datum Cantargia drar i dagarna i gång sin första amerikanska studie med CAN04. Upplägget skiljer sig från CANFOUR-programmet, som befinner sig i slutet av fas 2a.

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Open phase I/IIa study to assess safety and signs of efficay during treatment with CAN04. Phase I In the CANFOUR part examining PDAC, 9 patients in the first cohort of 31 are currently on treatment with CAN04 in combination with gemcitabine and nab-paclitaxel. An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control[1]. Cantargia: första patienten behandlad med antikroppen CAN04 i fas IIa-delen av CANFOUR-studien fre, jan 25, 2019 08:30 CET. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighet med det kliniska protokollet. Cantargia AB (publ) meddelar idag att den första patienten i fas IIa-delen av den kliniska studien CANFOUR erhållit behandling med CAN04 (nidanilimab) i enlighe Cantargia: Fas I säkerhetsutvärderingsdelen av CANFOUR studien med antikroppen CAN04 är genomförd och fas IIa-delen initieras fre, dec 07, 2018 15:30 CET. Cantargia AB (publ) meddelar idag att samtliga patienter i fas I-delen av den kliniska prövningen CANFOUR har fullföljt den formella säkerhetsutvärderingsdelen av studien.

Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC).

CAN04 is investigated in two clinical trials. CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung The results showed that CAN04 has a very high level of safety and positive effects on biomarkers that can be linked to cancer was observed. Good safety profile up to 10 mg/kg. A decrease in the biomarkers IL-6 and CRP. Stable disease in 43 per cent of patients.

CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different standard regimes in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC), as well as monotherapy in late stage patients (www.clinicaltrials.gov).

CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung The results showed that CAN04 has a very high level of safety and positive effects on biomarkers that can be linked to cancer was observed. Good safety profile up to 10 mg/kg.

These new Phase IIa data, combined with initial interim data reported in December 2019, continue to support the hypothesis that CAN04 has a synergistic benefit with chemotherapy, in our The CANFOUR trial investigates the antibody CAN04 for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. CAN04 is targeted against interleukin 1 receptor accessory protein (IL1RAP) and is studied both as single agent therapy as well as in combination with standard first line chemotherapy in NSCLC and pancreatic cancer, respectively. CAN04 i test med Keytruda Datum Cantargia drar i dagarna i gång sin första amerikanska studie med CAN04. Upplägget skiljer sig från CANFOUR-programmet, som befinner sig i slutet av fas 2a. Den amerikanska studien ska undersöka doser av CAN04 i kombination med världens mest sålda cancerpreparat, Keytruda, hos Cantargia completes recruitment and reports positive interim update in CAN04 pancreatic cancer combination therapy Thu, Oct 08, 2020 16:45 CET. Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 and chemotherapy have started treatment. Om CAN04 Antikroppen CAN04 binder starkt till målmolekylen IL1RAP och fungerar genom både ADCC och blockering av IL-1α- och IL-1β-signalering.
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CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker  Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 studeras i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker  Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to  Redeye bedömer att uppdaterade data från CANFOUR-studien ytterligare stärker utsikterna för antikroppsbehandlingen CAN04 och kan tala  CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in  Vi tror att den trend som CAN04 visade upp i de preliminära data som Även om CANFOUR-studien, som pågått sedan 2017, har dragits med  patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and First part of CANFOUR is nearing completion – Updated 16 May 2018 Cantargia's lead candidate is the antibody CAN04, which has a dual mechanism of  Syftet är en utökad satsning på Cantargias huvudprojekt CAN04 lovande subgruppen patienter i den pågående kliniska studien CANFOUR. Cantargia utvecklar antikroppen CAN04 för cancerbehandling.

mar 2020 CANFOUR - En doseopptrappingsstudie for å evaluere sikkerheten og toleransen av flere doser med CAN04-antistoff hos pasienter med solide  See Tweets about #canfour on Twitter. #Cantargia Reports Interim #Data from Phase 2A #CANFOUR Trial of CAN04 in #Pancreatic and #LungCancers  Cantargia reports treatment of first patient with antibody CAN04 in the phase IIa part of CANFOUR trial.
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Utgångspunkten är proteinet IL1RAP som är involverat i ett flertal sjukdomar och där Cantargia etablerat en plattform. Huvudprojektet, antikroppen CAN04, studeras i den kliniska fas I/IIa-studien CANFOUR med primärt fokus mot icke-småcellig lungcancer och bukspottskörtelcancer. Studien genomförs som både monoterapi och kombinationsterapi.

STOCKHOLM (Nyhetsbyrån Direkt) Forskningsbolaget Cantargia har inlett behandling av den första patienten i en utökning av Canfour-studien i fas 2a vid  i fas IIa extensionsdel av CANFOUR-studien i bukspottkörtelcancer Cantargia AB av CANFOUR studien som undersöker en kombination av CAN04 och  av CANFOUR studien som undersöker en kombination av CAN04 och cellgiftsbehandling. Extensionsdelen har designats för att ge ytterligare information som  Detailed Description: CAN04 is a first-in-class fully humanized and ADCC enhanced monoclonal antibody, targeting the Interleukin 1 Receptor Accessory Protein (IL1RAP). The CAN04 strategy is to attack the IL1RAP target molecule using an effective antibody-based cancer treatment. CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies.

Cantargia AB: Cantargia reports first patient treated with CAN04 in a US phase I study investigating combination with pembrolizumab. Publicerad: 2020-10-02 (Cision) Cantargia AB: Cantargia rapporterar att första patienten behandlats med CAN04 i en fas I studie i USA som studerar kombination med pembrolizumab

ska CAN04 dämpa den inflammatoriska nivån och hejda tumörtillväxten. Sedan början av 2019 driver Cantargia en fas 2a-studie, (CANFOUR) på patienter med metastaserad lung- och bukspottkörtelcancer utan tidigare behandling med cellgifter.

respons i 40% av patienterna (inkluderande 2 patienter som inte behandlats tillräckligt länge för en andra, bekräftande CT-scan), vilket är högre än historiska CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung According to the study protocol, the patients continue CAN04 (nidanilimab) treatment for biomarker and efficacy evaluation. Based on the positive outcome of the phase I safety evaluation, the phase IIa part of the trial can be started as planned. Cantargia is developing the antibody CAN04 for treatment of cancer. Cantargia AB meddelade idag att alla 31 planerade patienter med bukspottkörtelcancer (PDAC) har påbörjat behandling i CANFOUR-studien som undersöker kombination av CAN04 med cellgifter. Rapporterade interimsdata visade inga oväntade biverkningar, men noterbart är att fatigue (trötthet) och neuropati varit mindre vanligt än vad som förväntas med cellgifter, medan neutropeni var vanligare. 2021-03-31 · Cantargia is a clinical stage biotechnology company based in Sweden, established in 2009 and listed on Nasdaq Stockholm main market.